Simple screen used levels of two proteins to spot the disease with 95 percent accuracy, study found
WebMD News from HealthDay
FRIDAY, March 20, 2015 (HealthDay News) -- A urine test might someday become a much-needed early detection test for kidney cancer, a new study suggests.
"This research is very important and a significant finding, because we do not have a good screening mechanism for kidney cancer," said one expert, Dr. Ketan Badani, professor of urology at the Icahn School of Medicine in New York City.
The study was led by Dr. Evan Kharasch, professor of anesthesiology at Washington University School of Medicine. His team said that kidney cancer patients whose disease is diagnosed before the tumor spreads have an 80 percent survival rate.
However, if the cancer is not spotted until after it has spread, 80 percent of patients die within five years. According to the researchers, finding the disease early -- before it has spread -- has remained a major challenge.
"The most common way that we find kidney cancer is as an incidental, fortuitous finding when someone has a CT or MRI scan," Kharasch explained in a university news release. "It's not affordable to use such scans as a screening method, so our goal has been to develop a urine test to identify kidney cancer early."
In the new study, his team found that measuring levels of two proteins in urine was more than 95 percent accurate in identifying early stage kidney cancer, with no false-positive results triggered by the presence of non-cancerous kidney disease.
The investigators analyzed urine samples from 720 patients scheduled to undergo abdominal CT scans unrelated to a suspicion of kidney cancer, along with samples from 80 healthy people and 19 people previously diagnosed with kidney cancer.
The urine samples were checked for levels of the proteins aquaporin-1 (AQP1) and perlipin-2 (PLIN2). None of the healthy people had elevated levels of either protein, but kidney cancer patients had elevated levels of both proteins.
Three of the 720 people who had abdominal CT scans also showed elevated levels of both proteins. Two of those people were later diagnosed with kidney cancer, and the third died of other causes before a diagnosis was made, according to the findings published March 19 in the journal JAMA Oncology.
source : Urine Test Shows Promise for Early Diagnosis of Kidney Cancer