Wednesday, 4 March 2015

Surgery Patients Might Not Need Sedative Before Anesthesia


Experts say trend in U.S. is not to give patients these calming meds before procedure

WebMD News from HealthDay

By Steven Reinberg

HealthDay Reporter

TUESDAY, March 3, 2015 (HealthDay News) -- A new French study questions the need for giving a sedative to surgical patients to calm them down before anesthesia is administered.

The investigators found that the sedative lorazepam (Ativan) did not improve patients' experience, and was tied to a lower rate of early mental recovery.

"I was not surprised with these results," said Dr. J.P. Abenstein, president of the American Society of Anesthesiologists, who had no part in the study. "Lorazepam is a long-acting sedative lasting about 12 hours."

Abenstein said lorazepam is not generally used for surgery in the United States, but is used to treat people who have serious anxiety problems and for alcoholics to help them deal with alcohol withdrawal. "It is not the common drug used for sedation before surgery," he said.

When a sedative is called for, the most commonly used drug is midazolam, which is a short-acting sedative in the same class of drugs as lorazepam, said Abenstein, who is also an associate professor of anesthesiology at the Mayo Clinic in Rochester, Minn.

Most patients, however, are not sedated before an operation. "In my practice, we sedate very few patients before surgery, maybe one out of 100 patients, and that's a high estimate. It just doesn't come up that often," he said.

Among older patients, Abenstein said, sedatives like lorazepam or midazolam have been associated with psychosis and an increased risk of death. "You really don't need a sedative before surgery," Abenstein added.

The report was published in the March 3 issue of the Journal of the American Medical Association.

In the French study, a team led by Dr. Axel Maurice-Szamburski, of the Hopital de la Timone Adulte in Marseille, randomly assigned slightly more than 1,000 adults younger than 70 who were having elective surgery to receive lorazepam, or an inactive placebo, or no medication before anesthesia.

The researchers found that lorazepam did not improve overall patient satisfaction, compared with no medication or a placebo. Even among the most anxious patients, the study found no significant differences in patient satisfaction between the groups.

source : Surgery Patients Might Not Need Sedative Before Anesthesia

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