Class of drugs interferes with a key brain chemical, but study can't prove cause-and-effect
WebMD News from HealthDay
By Robert Preidt
HealthDay Reporter
MONDAY, Jan. 26, 2015 (HealthDay News) -- Long-term and/or high-dose use of a class of medications used for hay fever, depression and other ills has been linked in a new study to a higher risk of dementia.
The drugs -- called anticholinergics -- include nonprescription diphenhydramine (Benadryl) and tricyclic antidepressants like doxepin (Sinequan). This class of medications also includes older antihistamines like chlorpheniramine (Chlor-Trimeton) and "antimuscarinic" drugs for bladder control, such as oxybutynin (Ditropan).
However, the study could only point to an association between long-term or high-dose use of these drugs and a higher risk of dementia, it could not prove cause-and-effect.
Also, the relationship "did not occur at the lowest dosage range but did occur at higher dosages used long-term," said one expert, Dr. Alan Manevitz, a clinical psychiatrist at Lenox Hill Hospital in New York City. He was not involved in the new study.
Manevitz also stressed that consumers "should not abruptly stop any current medication treatment but rather should first consult with their physician."
The new study was led by Shelly Gray of the Group Health Research Institute-University of Washington. Her team explained that the anticholinergic class of medications work by blocking a neurochemical called acetylcholine, in both the brain and body.
Manevitz noted that people "suffering from Alzheimer's disease typically show a marked shortage of acetylcholine."
The new study tracked outcomes for more than 3,500 seniors who were followed for more than seven years. Gray's group found that people who took at least 10 milligrams per day of Sinequan, 4 mg per day of Benadryl, or 5 mg per day of Ditropan for more than three years were at greater risk for developing dementia.
Manevitz noted that occasional use of these medications did not seem to be tied to a rise in dementia risk. "The risk of dementia was due to a cumulative total of exposure, not to an acute short course of treatment," he said.
And, Gray said in an institute news release, "Older adults should be aware that many medications -- including some available without a prescription, such as over-the-counter sleep aids -- have strong anticholinergic effects. And they should tell their health care providers about all their over-the-counter [drug] use," she added.
source : Use of Certain Allergy, Depression Meds Tied to Higher Odds for Dementia
