Review of 13 trials finds little effect for drug best recognized as Tylenol
WebMD News from HealthDay
By Robert Preidt
TUESDAY, March 31, 2015 (HealthDay News) -- Acetaminophen -- best known as Tylenol in the United States -- does not appear to help ease lower back pain and offers little relief for the most common form of arthritis, according to a new report.
The review of data from 13 studies could challenge existing recommendations on pain relief, experts say.
"These results support the reconsideration of recommendations to use [acetaminophen] for patients" with these conditions, concluded a team led by Gustavo Machado of The George Institute for Global Health at the University of Sydney in Australia.
Osteoarthritis -- the most common form of arthritis -- and back pain are among the leading causes of disability worldwide, the researchers said. Current clinical guidelines recommend acetaminophen as the first-line drug treatment for both conditions.
However, doubts about the effectiveness of the drug in treating the conditions, and concerns about the safety of the recommended full dose (up to 4,000 milligrams a day), have made those guidelines controversial, Machado's team said.
Looking at the pooled data, the investigators found that for people with lower back pain, acetaminophen was ineffective in either reducing patient disability or enhancing quality of life.
In people with osteoarthritis of the hip or knee, acetaminophen provided only a small, not clinically important benefit in the reduction of pain and disability, the study found.
McNeil Consumer Healthcare, the maker of Tylenol, countered that acetaminophen has a long history of effectiveness.
In a statement, the company said that before clinical guidelines are changed, "it is important to comprehensively look at the body of evidence . . . The safety and efficacy profile of acetaminophen is supported by more than 150 studies over the past 50 years."
And one U.S. expert also urged caution.
"Part of the problem of comparing many trials is the benefit to an individual patient is lost," said Dr. Houman Danesh, director of integrative pain management at Mount Sinai School of Medicine in New York City.
source : Study Casts Doubt on Acetaminophen for Low Back Pain, Arthritis