Thursday, 9 April 2015

Antibody Holds Promise as Weapon Against HIV


Treatment would complement existing medications, researchers say

WebMD News from HealthDay

By Randy Dotinga

HealthDay Reporter

WEDNESDAY, April 8, 2015 (HealthDay News) -- Therapy with a human antibody appears to reduce levels of the HIV virus in the blood for at least a month, preliminary research suggests.

Antibodies are the part of the immune system that develop to fight infections. Use of these antibodies as a treatment is called immunotherapy.

The antibody "might be able to intensify current treatment strategies," said study co-author Dr. Florian Klein an assistant professor of clinical investigation at Rockefeller University in New York City, especially since this new treatment appears to be more potent than previous attempts at HIV immunotherapy.

The researchers acknowledged that this antibody treatment would have to be combined with HIV drugs or another antibody.

And much more research is needed before this treatment could even be used as an add-on therapy. The current study represents just the first level of three phases of research required of drugs before they can be approved in the United States. It's also possible that more side effects might become evident as more people try the treatment.

So far, researchers haven't been able to turn immunotherapy into a weapon against HIV -- the virus that causes AIDS -- although there's been research into its use both as a treatment and as a vaccine to prevent infection.

In the meantime, another kind of treatment has revolutionized the treatment of HIV over the past 20 years or so: antiretroviral medications. These medications have turned HIV from a fatal diagnosis into a chronic disease. They work by disrupting the machinery that allows the virus to replicate and enter cells.

Antibodies work a bit differently. They "can bind to critical areas on the virus that are required to infect human cells," Klein explained. "If these sites are blocked by the antibody, the virus cannot infect them. Moreover, antibodies can bind to the virus and engage other immune cells of the patient to eliminate the virus."

In the new study, researchers turned to an antibody known as 3BNC117 that targets HIV. These type of antibodies are only produced naturally by about 10 percent to 30 percent of people with HIV, according to the researchers.

source : Antibody Holds Promise as Weapon Against HIV

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